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KMID : 0378119860130020324
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Chungnam Medical Journal
1986 Volume.13 No. 2 p.324 ~ p.330
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The Effect of D-Tubocurarine on the Blood Pressure and Heart Rate in Endotracheal Intubation
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Abstract
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Transient increase in blood pressure and heart rate following laryngoscopy, endotracheal intubations are common.
Tomori and Widdi can be found these response are associated with an increased impulse traffic in the cervical sympathetic efferent nerve fiber.
These nervous activities were especially increased by mechanical stimulation of the epi-and laryngopharyngeal region.
The present study was undertaken to observe the effect of d-Tubocurarine on the blood pressure and heart rate in endotracheal intubation.
d-Tubocurarine is one of the non-deporalizing muscle-relaxants which is commonly used in clinical situation. The most common side effect of d-Tc in a dose-related falls in arterial pressure.
Adult patients who had received elective surgery under general anesthesia with endotracheal intubation randomly selected in Chungnam University hospital. Sixty patients were selected for the response of d-Tc following intubation, and these were divided into 4 group each:
Group Ⅰ : Served as a control group for intubation(n=15, no intravenous d-Tc)
Group Ⅱ : Served as a intravenous d-Tc(3mg) injected group before intubation(n= 15).
Group Ⅲ : Served as a intravenous d-Tc(6mg) injected group before intubation(n= 15).
Group Ⅳ : Served as a intravenous d-Tc(9mg) injected group before intubation(n= 15).
The results were as follow.
1) The elevation of systolic B.P. following intravenous d-Tc injection before intubation was of less magnitude than in control group. (Statistically significant, esp. group Ⅳ).
2) The elevation of diastolic B.P. following intravenous d-Tc injection before intubation was of less magnitude than in control group (Statistically significant).
3) The elevation of heart rate following intravenous d-Tc injection before intubation was not significant compared with control group.
It is suggested from the above results that the d-Tc intravenous injection before intubation decrease the magnitude of blood pressure elevation but not decrease the magnitude of H.R. elevation following intubation.
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